WHO recommends cheap and readily available steroids as Covid-19 treatment
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London — Treating critically ill Covid-19 patients with corticosteroid drugs reduces the risk of death by 20%, an analysis of seven international trials found on Wednesday, prompting the World Health Organisation (WHO) to update its advice on treatment.
The analysis — which pooled data from separate trials of low dose hydrocortisone, dexamethasone and methylprednisolone — found that steroids improve survival rates of Covid-19 patients sick enough to be in intensive care in hospital.
“This is equivalent to around 68% of (the sickest Covid-19) patients surviving after treatment with corticosteroids, compared to around 60% surviving in the absence of corticosteroids,” the researchers said in a statement.
“Steroids are a cheap and readily available medication, and our analysis has confirmed that they are effective in reducing deaths among the people most severely affected by Covid-19,” Jonathan Sterne, a professor of medical statistics and epidemiology at Britain's Bristol University who worked on the analysis, told the briefing.
He said the trials — conducted by researchers in Britain, Brazil, Canada, China, France, Spain, and the US — gave a consistent message throughout, showing the drugs were beneficial in the sickest patients regardless of age or sex or how long patients had been ill.
The findings, published in the Journal of the American Medical Association, reinforce results that were hailed as a major breakthrough and announced in June, when dexamethasone became the first drug shown to be able to reduce death rates among severely sick Covid-19 patients.
Dexamethasone has been in widespread use in intensive care wards treating Covid-19 patients in some countries since then.
Martin Landray, a professor of medicine and epidemiology at the University of Oxford who worked on the dexamethasone trial that was a key part of the pooled analysis published on Wednesday, said the results mean doctors in hospitals across the world can safely switch to using the drugs to save lives.
Clear benefits
“These results are clear, and instantly usable in clinical practice,” he told reporters. “Among critically ill patients with Covid-19, low-dose corticosteroids ... significantly reduce the risk of death.”
Researchers said the benefit was shown regardless of whether patients were on ventilation at the time they started treatment. They said the WHO would update its guidelines immediately to reflect the fresh results.
Until the June findings on dexamethasone, no effective treatment had been shown to reduce death rates in patients with Covid-19, the respiratory disease caused by the ...
The analysis — which pooled data from separate trials of low dose hydrocortisone, dexamethasone and methylprednisolone — found that steroids improve survival rates of Covid-19 patients sick enough to be in intensive care in hospital.
“This is equivalent to around 68% of (the sickest Covid-19) patients surviving after treatment with corticosteroids, compared to around 60% surviving in the absence of corticosteroids,” the researchers said in a statement.
“Steroids are a cheap and readily available medication, and our analysis has confirmed that they are effective in reducing deaths among the people most severely affected by Covid-19,” Jonathan Sterne, a professor of medical statistics and epidemiology at Britain's Bristol University who worked on the analysis, told the briefing.
He said the trials — conducted by researchers in Britain, Brazil, Canada, China, France, Spain, and the US — gave a consistent message throughout, showing the drugs were beneficial in the sickest patients regardless of age or sex or how long patients had been ill.
The findings, published in the Journal of the American Medical Association, reinforce results that were hailed as a major breakthrough and announced in June, when dexamethasone became the first drug shown to be able to reduce death rates among severely sick Covid-19 patients.
Dexamethasone has been in widespread use in intensive care wards treating Covid-19 patients in some countries since then.
Martin Landray, a professor of medicine and epidemiology at the University of Oxford who worked on the dexamethasone trial that was a key part of the pooled analysis published on Wednesday, said the results mean doctors in hospitals across the world can safely switch to using the drugs to save lives.
Clear benefits
“These results are clear, and instantly usable in clinical practice,” he told reporters. “Among critically ill patients with Covid-19, low-dose corticosteroids ... significantly reduce the risk of death.”
Researchers said the benefit was shown regardless of whether patients were on ventilation at the time they started treatment. They said the WHO would update its guidelines immediately to reflect the fresh results.
Until the June findings on dexamethasone, no effective treatment had been shown to reduce death rates in patients with Covid-19, the respiratory disease caused by the ...